Immunogenic Properties of Streptococcus agalactiae FbsA Fragments
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چکیده
منابع مشابه
Immunogenic Properties of Streptococcus agalactiae FbsA Fragments
Several species of Gram-positive bacteria can avidly bind soluble and surface-associated fibrinogen (Fng), a property that is considered important in the pathogenesis of human infections. To gain insights into the mechanism by which group B Streptococcus (GBS), a frequent neonatal pathogen, interacts with Fng, we have screened two phage displayed genomic GBS libraries. All of the Fng-binding ph...
متن کاملThe fibrinogen receptor FbsA promotes adherence of Streptococcus agalactiae to human epithelial cells.
Streptococcus agalactiae is a major cause of bacterial pneumonia, sepsis, and meningitis in human neonates. During the course of infection, S. agalactiae adheres to a variety of epithelial cells but the underlying mechanisms are only poorly understood. The present report demonstrates the importance of the fibrinogen receptor FbsA for the streptococcal adherence and invasion of epithelial cells....
متن کاملHEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY FbsA, a fibrinogen-binding protein from Streptococcus agalactiae, mediates platelet aggregation
The bacterium Streptococcus agalactiae is an etiologic agent in the pathogenesis of endocarditis in humans. FbsA, a fibrinogen-binding protein produced by this pathogen, is considered an important virulence factor. In the present study we provide evidence that S agalactiae clinical isolates bearing FbsA attach to fibrinogen and elicit a fibrinogen-dependent aggregation of platelets. Mutants of ...
متن کاملFbsA, a fibrinogen-binding protein from Streptococcus agalactiae, mediates platelet aggregation.
The bacterium Streptococcus agalactiae is an etiologic agent in the pathogenesis of endocarditis in humans. FbsA, a fibrinogen-binding protein produced by this pathogen, is considered an important virulence factor. In the present study we provide evidence that S agalactiae clinical isolates bearing FbsA attach to fibrinogen and elicit a fibrinogen-dependent aggregation of platelets. Mutants of ...
متن کاملStreptococcus agalactiae
Streptococcus agalactiae, a unique bacterium commonly referred to as group B streptococcus (GBS), is evolving to become a major pathogen that causes a wide variety of problems across a broad spectrum of individuals. The greatest controversy over this bacterium involves the obstetrical patient. Lawyers have made this organism a centerpiece, leading their clients to believe that the presence of G...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2013
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0075266